Endocrine Abstracts

Mitochondria are essential for the fuel-stimulated processes in beta-cells that control insulin secretion. Indeed, mutations in mitochondrial DNA underlie rare forms of maternally-inherited diabetes, where insulin secretion is impaired. Studies in human islets have identified several perturbations of mitochondrial function but whether they are causal or not has not been determined. Mining data from genome-wide association studies led us to the discovery of a variant of TFB...